The impact of hereditary thrombophilias in recurrent pregnancy loss

Introduction: Recurrent pregnancy loss (RPL) is defined as two or more consecutive which occurs before the 20th weeks of pregnancies for last menstrual period. Hereditary cause thrombophilic gene mutations and polymorphism may play an essential role in RPLs. Material Method: 291 women with a history abortions study group 61 without miscarriages control were included study. In this we analysed effects Factor II Prothrombin mutation ,FV Leiden mutation, MTHFR C677T, MTHFT A1298C, PAI-1, ?-fibrinogen, XIIIA (V34L) Glycoprotein IIIa (L33P) polymorphisms on RPL by using pyrosequencing. Chi-square multiple regression analysis used statistical analysis. Results: FII prothrombin FV PAI1 Beta fibrinogen found statistically significant chi-square test. Heterozygous G1691A (OR:8.092, CI: 1.280-51.165), homozygous A1298C (OR:17.621, 3.644 - 85.203), C677T (OR: 2.921 0.811-10.515), Homozygous 3.619 1.647-7.954), heterozygous 5.989, 2.574-13.934), 8.756, 2.805 -27.334), ( OR: 7.114, 3.145- 16.096) FibrinogenG455A (4.085, 1.438-11.610) logistic RPL(p<0.05). Discussion: This indicated that there association between thrombophilias RPL. Therefore, it important to detect